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These overlapping functions include facilitation of LTP and calcium signaling, memory enhancement, vascular angiogenesis, facilitation of blood flow and cerebroprotection, augmentation of dendritic arborization and synaptogenesis, and neurogenesis [48]

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Alterations in BA composition and concentration may impair the activity of hepatic FXR and TGR5 ( Excessive lipid accumulation contributes to elevated UA levels in gout patients

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doi: 10.1016/j.ejps.2019.04.011 18 LevineBKroemerG