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This multimeric complex facilitates the autocatalytic activation of caspase-1, an inflammatory caspase, which cleaves pro-IL-1 and pro-IL-18 into their mature, biologically active forms, IL-1 and IL-18

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Recent research has shown that hyperglycemia induced cellular stress, such as ERS (120) and oxidative stress (119), which stimulate the pyroptotic process in renal cells, and various signaling pathways, such as TLRs/NF-B/NLRP3 inflammasome signalling pathway, TXNIP/NLRP3 inflammasome pathway, ATP/P2X purinergic signalling pathway, and MAPKs/NLRP3 inflammasome signalling pathway (119, 121)

The recommended dietary allowance (RDA) for zinc for adult women and men is 8 to 11 mg per day, respectively