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J Membr Sci

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Pre-existing risk factors include: Men and those over 40 (though post-menopausal women also face increased risk) Family history of gout or hyperuricaemia Obesity itself , which is associated with higher uric acid production Metabolic syndrome , including hypertension, dyslipidaemia, and insulin resistance Chronic kidney disease , which impairs uric acid excretion Certain medications , such as diuretics (particularly thiazides), low-dose aspirin, and ciclosporin Dietary factors that may interact with weight loss treatment include: High intake of purine-rich foods (red meat, organ meats, certain seafood) Excessive alcohol consumption, particularly beer and spirits High-fructose beverages and foods Dehydration or inadequate fluid intake Weight loss-specific considerations are particularly relevant for Saxenda users

Eligibility typically depends on BMI and whether individuals have weight-related health conditions

However, it has been shown that a network pharmacology-based approach can reveal therapeutic targets

The Link Between GLP-1 Agonists and Appetite Control Current Evidence: Do GLP-1 Medications Help With Binge Eating