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2022 Mar 2;11(3)

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This binding site is deeply buried within the core of the transporter protein and is structurally formed by amino acids located on Transmembrane Helices (TMHs) 1, 3, 6, and 8 (Beuming et al., 2008

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A specific oxidoreductase, previously known as apoptosis-inducing-factor mitochondrial-2 (AIFM2), capable of recycling reduced ubiquinol (Co-enzymeQ 10 H 2 ) from ubiquinone at the expense of NAD(P)H, has been presented as a potential ferroptosis inhibitor due to the fact that its overexpression complements the loss of GPx4 in PFA1 and human fibrosarcoma (66, 67)