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Excessive refines carbohydrates and scarce micronutrients intakes increase inflammatory mediators nd insulin resistance in prepubertal and pubertal obese children independently of obesity

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The change of objective function value (OFV) was used as the covariate inclusion criteria

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Calorie restriction also negatively influences the circulating insulin-like growth factor-1 (IGF-1) levels, thereby impacting multiple cellular pathways known for cancer proliferation