If Cost Plus pricing reduces that acquisition cost by 30% a conservative estimate for drugs currently dispensed through PBM-affiliated specialty pharmacies the savings are $1.2 million per year
The New England Journal of Medicine commentary accompanying SURPASS-2 stated: "The dual incretin approach appears to exploit receptor crosstalk in ways that amplify downstream insulin secretion beyond what GLP-1 receptor agonism alone can achieve at comparable tolerability." [30] SURPASS-1: Monotherapy Benchmark SURPASS-1 (N=478) established monotherapy efficacy, with tirzepatide 15 mg reducing A1C by 2.07 percentage points and body weight by 9.5 kg at 40 weeks versus placebo [31]
BMI helps healthcare providers classify weight categories and assess potential health risks
Over and over again, the FDA came back to a major sticking point: Its unclear, chemically, what these peptides even are
We need plenty of NAC to produce enzymes (in particular ADH and ALDH) that clear out acetaldehyde
At 1 mg/mL, a 2.4 mg dose would require 240 units, far beyond what any standard insulin syringe can hold