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Therefore, regardless the clinical heterogeneity or underpinning genetics, the different forms of PD share a common etiology in mitochondrial dysfunction and oxidative stress

Fatigue or Drowsiness What happens: Feeling unusually tired after treatment

For example, certain FTO variants are associated with higher baseline appetite set-point, potentially making GLP-1 agonists more impactful

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While enzymes such as glutathione peroxidase 4 (GPx4) typically utilize cellular glutathione (GSH) stores to scavenge lipid hydroperoxides and prevent LPO-induced damage, erastin-mediated inhibition of cysteine uptake through the Xc- transporter compromises this defense strategy, leading to cell death