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Studies had found that gut microbiota abundance was significantly altered in CKD and ESRD patients, some of them are TMA producing bacteria, such as Firmicutes (Vaziri et al., 2013

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They may also harbor bacteria, increasing infection risk, and can introduce air bubbles into the pen, affecting dose accuracy

However, many individuals may struggle to maintain adequate levels of this vital nutrient due to factors such as dietary restrictions, malabsorption issues, or lifestyle choices

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