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Signs and Symptoms of Vitamin B12 Deficiency Vitamin B12 deficiency can lead to various health concerns, including: Fatigue and low energy levels Pale or jaundiced skin Breathlessness or dizziness Pins and needles or numbness Muscle weakness Mood changes, including depression For more information about Vitamin B12 deficiency symptoms, visit the NHS website

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It is also possible that in active acromegaly, chronic exposure to elevated IGF-I levels resets IGF-IR responsiveness via the induction of IGF-IR resistance (70), as it has been demonstrated that prolonged stimulation with IGF-I induces functional IGF-IR resistance in vitro through the negative feedback loop (72)