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However, the requirement for HSL phosphorylation has recently been challenged as studies by the Granneman group elegantly show that direct activation of PNPLA2 in the absence of PKA stimulation is sensitive to HSL inhibition, suggesting that PNPLA2-mediated generation of DAG is sufficient to promote HSL activity (49)

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Semaglutide: The GLP-1 Pathway Semaglutide is a GLP-1 receptor agonist with 94% homology to native GLP-1 and a ~7-day half-life achieved through C18 fatty acid acylation and DPP-4 resistance (Muller et al., 2021)

"Regulation of JNK signaling by GSTp"