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A 2022 meta-analysis published in Cardiovascular Diabetology examining GLP-1 receptor agonist effects on lipid profiles found that semaglutide and tirzepatide produced statistically significant reductions in triglycerides across all trials examined, with the magnitude of reduction correlating with both the degree of weight loss achieved and baseline triglyceride levels, supporting the clinical rationale for GLP-1 use in patients with hypertriglyceridemia alongside obesity

If additional glycaemic control is required, the dose may be further increased to 14 mg daily after at least one month on the 7 mg dose

Wolk R, Somers VK

Zinc depletion with prolonged supplementation 2

With growing evidence of NEO neurotoxicity, there is an urgent need for a better understanding of their negative effects on nontarget organisms (Wang et al

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