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For personal cosmetic use, pre-formulated serums are acceptable if you commit to refrigeration and use within 6090 days of opening.

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The effects of TGF-1 are exerted through the transcription factor SMAD3 which binds to an intronic region of PPAR- gene

Serum-free or low-serum conditions are essential because serum IGFBPs in the media would partially sequester even LR3 at the highest serum concentrations