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In rodent studies, orally administered curcumin was primarily detected in the stomach and small intestine, accounting for approximately 90% of the curcumin, with only trace amounts of unchanged curcumin in the liver and kidney (124, 125)

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Cycle time values exceeding the threshold were normalized to the housekeeping gene TBP and used as a quantification of the qPCR

It stabilizes IkB-alpha, blocks p65 nuclear translocation, and suppresses MAPK activation, effectively turning off the transcriptional program that drives sustained inflammation