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Then, 6-phosphogluconate dehydrogenase (PGD) that often functions as a homodimer catalyzes the oxidative decarboxylation of 6-phosphogluconate (6-PG) to synthesize ribulose-5-phosphate (Ru5P) and a second NADPH in the third reaction

doi: 10.1164/rccm.200709-1400OC

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These results strongly indicate that a Gpx4 CIRT transcript represents an unprocessed variant of the n- Gpx4 mRNA isoform