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Accordingly, some interpretations should be considered as hypothesized or proposed mechanisms that require further empirical confirmation

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In this review, we not only gathered the most recent discoveries on MTHFR polymorphism and related DNA methylation in various psychiatric disorders, but also highlighted the potential relationships between MTHFR activity and implication of folate-related function in specific mental diseases

Such factors are often intertwined with broader social determinants of health that disproportionately affect minority communities

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