Nevertheless, if its senolytic action has been demonstrated in several diseases such as osteoarthritis 15,16 as well as in neurodegenerative diseases 17 , the effect of ABT-263 is restricted to senescent cells from specific cell types 18 , leading to the necessity to identify new potential senolytics to target senescent cells in age-related diseases
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Wexler AG, Schofield WB, Degnan PH, Folta-Stogniew E, Barry NA, Goodman AL
Glutathione interrupts this process through multiple mechanisms: it inhibits the enzyme tyrosinase, which catalyzes melanin production
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