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Major depressive disorder is intricately linked with compromised neurogenesis and diminished expression of neurotrophic factors, particularly brain-derived neurotrophic factor (BDNF)

While preliminary findings suggest the safety of 5-amino-1MQ, clinical data is still lacking, and continuous scrutiny is essential for researchers to understand its effects across diverse demographic groups

Maeda, D

It is found that shikonin can stimulate RIPK1 and RIPK3-dependent necrosis and directly promote the up-regulation of DAMPs through autophagy, in which ROS accumulation and NF-B pathway activation may be the main mechanisms of cell necrotizing apoptosis (121)

10.1080/13543784.2019.1672657 97 MsperoJ

Table 1 The experimental protocol and groups