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Store it frozen at -20C (-4F) for long-term storage, where it remains viable for years

While a 23G needle that is short enough (e.g., 5/8 inch) will physically deposit the medication in the right tissue layer, a 23G needle is much thicker than the standard 25G30G SubQ needles

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To apply this methodology to the anti-Met macrocycles, we designed precursor macrocycles bearing a short peptide motif containing a Cys residue at the C terminus and modified the sulfhydryl group with three bis-maleimide cross-linkers with different lengths, C6, PEG3 and PEG11 (Supplementary Table 2)

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