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But two issues hold it back from a better score

The differences in these medications lie primarily in their formulation as well as how the body responds to them over time

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Prasad-Reddy L, Kerner D

One study showed that applying 0.075% capsaicin (the substance that gives chili peppers their heat) to affected areas three times daily for 6 weeks, in addition to taking standard medication, improved pain in people with severe fibromyalgia better than taking medication alone

Liraglutide, injectable semaglutide, and dulaglutide have FDA-recognized cardiovascular risk reduction in patients with established cardiovascular disease, while Wegovy is indicated for cardiovascular risk reduction in adults with established cardiovascular disease and either overweight or obesity