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Abstract Recently, nicorandil exerted antinociception via TRPV1/opioid signaling

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Wilding JP, Batterham RL, Calanna S, Davies M, Van Gaal LF, Lingvay I, et al

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They are not a prescription, and no dose here should be read as a personal recommendation

For gut-specific endpoints, local mucosal exposure is sufficient for effect even without systemic absorption, because the target tissue (GI lining) is already in direct contact with the compound