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Conversely, following hypoxia or loss of mitochondrial membrane potential, the inactivation or reduction of tyrosine kinase activity through the activation of PGAM5 will contribute to the downregulation of the phosphorylated FUNDC1 level

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[DOI] [PubMed] [Google Scholar] 23.Bishop GM, Robinson SR

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It is genetically inherited and considered an independent risk factor for heart disease