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Highlights This paper systematically reviews the relationship between nutrition, microbiota, and depression

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Importantly, IL-6 elevation occurred without corresponding CRP increases, and IL-6 correlated with IL-8, suggesting persistent immune activation rather than nonspecific inflammation

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Increased interest in health, disease prevention and treatment, aging populations, urbanization, and public awareness of nutrition have led to the development and introduction of several health-benefitting products namely functional foods, herbal medicines, and their products [1]