Potential Causes of Allodynia Allodynia is associated with several neurological and metabolic conditions, including: Peripheral Neuropathy (due to diabetes, chemotherapy, or autoimmune disorders) Fibromyalgia (central pain sensitisation disorder) Migraine Disorders (involving trigeminal nerve hypersensitivity) Neuroinflammation and Immune Dysregulation (as seen in post-viral syndromes) Medication Side Effects, including possible links to GLP-1 receptor agonists Mechanisms: How GLP-1 Medications May Contribute to Allodynia GLP-1 receptor agonists (e.g., Mounjaro, Wegovy) are widely used for weight loss and glycemic control due to their role in glucose-dependent insulin secretion and appetite suppression
In contrast, inheritance of HLA-DR beta 1*07, DQB1*0201, DQB1*0502, and DQB1*0602 appear to be protective (128, 129)
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It can be prescribed to adults with obesity who have a body mass index (BMI) of 30 or above, or who are overweight with a BMI between 27 and 30 and at least one weight-related comorbidity, and should be used alongside a reduced-calorie diet and increased physical activity
126 MinatoT.MaedaT.FujisawaY.TsujiH.NomotoK.OhnoK.et al (2017)