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How should researchers compare variants

Given that the Denmark-based Novo Nordisk reportedly earned nearly $5 billion in 2021 sales for its Liraglutide and Semaglutide class drugs, it seems reasonable at first glance that they would find it in their economic interest to increase production to meet demand

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2 Search strategy and inclusion criteria This mini-review was based on a targeted literature search conducted in PubMed/MEDLINE and Scopus from January 2015 to August 2025, using the keywords GLP-1 receptor agonists, exercise, physical activity, obesity, type 2 diabetes, and weight loss. Additional terms ( lean mass, body composition, insulin sensitivity, cardiometabolic, combined intervention ) were used in secondary searches

Research also indicates that GLP-1 receptor agonists like semaglutide can help prevent the weight loss-associated decrease in free leptin production by adipose tissue and promote the synthesis of Peptide YY (3-36) by endocrine cells in the human small intestine, which may promote long-term appetite and body weight control [11]

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