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The FDA lists suicidal behavior on its website as a possible side effect of Wegovy and Saxenda
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Mechanism Comparison Semaglutide single GLP-1 receptor agonist Semaglutide activates one pathway: GLP-1 receptor slows gastric emptying, increases satiety, enhances glucose-dependent insulin secretion, and acts on central appetite circuits
& Vancurova, I
The 3-week washout recovery Week 1 (Oct 2-8) : HRV averaged 28ms, lowest HR 63 bpm (still suppressed) Week 2 (Oct 9-15) : HRV improved to 28ms, lowest HR 63 bpm (plateau, no improvement) Week 3 (Oct 16-22) : HRV jumped to 35ms, lowest HR 57 bpm (some recovery!) From 25ms to 35ms in 3 weeks - a 40% improvement just from getting off the drugs
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