If side effects are manageable and results are progressing at a moderate dose, there is no requirement to keep increasing
Effect of Pentoxifylline on renal function and urinary albumin excretion in patients with diabetic kidney disease: the PREDIAN trial
The Mayo Clinic said the supplement "may be safe when taken in recommended amounts" with the main side effects including nausea, constipation, diarrhea, gas and vomiting
Most were mild to moderate and tended to occur during dose increases, similar to the pattern seen with semaglutide and tirzepatide.[1] A finding worth flagging: in the obesity trial, retatrutide produced small increases in heart rate (about 5 to 7 beats per minute on average at the higher doses).[1] Heart rate increases have also been seen with other drugs in this class, but the size in retatrutide was on the higher end
Symptoms include heavy periods, breast tenderness, water retention, and mood changes
Inorganic nanoparticles are simpler to produce and modify but raise concerns about biocompatibility