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GLP-1 Assisted Transition to Suzetrigine or Other Non-Addictive Painkillers Does semaglutide or tirzepatide (given at first visit and ongoing) increase the success rate of transitioning chronic pain patients from opioids to suzetrigine, aka Vertex VX-548

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Safety Profile and Monitoring The most common adverse effects of tirzepatide are gastrointestinal: nausea (up to 31%), diarrhea (17%), and decreased appetite (14%) in the SURPASS program pooled data [7]