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From these, we extracted E max and EC 50 by applying stringent multiple testing correction ( P 1)

Applying heat to the patch site : Exposure to external heat sources (hot baths, saunas, heating pads, or direct sunlight) can increase drug absorption rates unpredictably, potentially leading to adverse effects

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It is known to enhance sperm quality in men and egg quality in women, thus increasing the chances of conception

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Dose titration strategy is critical