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FOXO4 is localized within the promyelocytic leukemia body in senescent cells and interacts with p53, inhibiting its nuclear exclusion 34

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doi: 10.1097/00004872-200306000-00012

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Subsequent research uncovered that the HGF-MET signaling pathway triggers the PI3K pathway, which in turn triggers Arg-1 expression in a dependent manner, propelling M1 macrophages to adopt an M2-like phenotype [66]

Glucagon agonism in the treatment of metabolic diseases including type 2 diabetes mellitus and obesity