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150 An uncontrolled trial in 60 men with infertility, despite having normal sperm counts, found 5 grams of ashwagandha root powder daily for 90 days reduced levels of markers of psychological stress, decreased semen oxidative stress, and resulted in a 14% pregnancy rate

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PMID 27138887

Additionally, patients with CD have lower levels of antioxidative substances such as plasma ascorbic acid, - and -carotene, lycopene, and -cryptoxanthin, as well as tissue GSH, which takes part in GPx-catalyzed H 2 O 2 reduction (161)

Although many cell and animal studies support these mechanisms, we still lack long-term clinical data to track ferroptosis during DKD progression

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