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The evidence for physical activity in the management of major mental illnesses: a concise overview to inform busy clinicians' practice and guide policy

It can be characterised by painful swallowing

This inconsistency sometimes leads people to think the medication has stopped working when the issue is actually variable absorption from inconsistent technique

A large retrospective cohort study published in early 2026 (Barnett et al., Cureus) matched nearly 390,000 diabetic patients on GLP-1 therapy against a similar number not on GLP-1 therapy 4

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However, clinical trials have shown minimal hypoglycemia with alpha-cell-targeting incretin therapies, likely because they reduce glucagon in a glucose-dependent manner