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Additionally, the upregulation of inflammation-related genes, such as IL-6 and TNF-, is associated with the pathological state of depression, suggesting that immune responses play a critical role in its pathogenesis [365, 366]

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Environmental and intrinsic factors affect the gut biome, the milieu of nutrients present in the large intestine greatly affect hunger signalling

Consensus Statement on the Role of Glutathione and Vitamin C Supplementation in Gut Dysbiosis Management.