Since then, more potent GLP-1 and dual agonists (targeting both GLP-1 and GIP) have been approved, including for weight loss in those living with obesity
However, DULs long-term efficacy and safety need to be further studied
RF: Conceptualization, Investigation, Writingoriginal draft, Writingreview & editing, Supervision, Project administration
Future studies should optimize these management strategies and strengthen multimodal interventions to reduce complication rates and improve patient quality of life
doi: 10.1210/jc.2017-02006 25 JonesLABrierleyDI
Beads were initially equilibrated in 20 mM Tris-HCl pH 8.0, 300 mM NaCl binding buffer, followed by incubation with 50 M His-tagged Syn constructs (Syn WT or Syn 1103 ) for 45 min at 4 C with gentle rotation