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doi: 10.1111/j.1523-5378.2009.00686.x 44 DingSZMinoharaYFanXJWangJReyesVEPatelJet al

Toxicological significance of liver hypertrophy produced by inducers of drug-metabolizing enzymes

doi: 10.1016/j.abb.2004.05.011 153 TallaS.RiazunnisaK.PadmavathiL.SunilB.RajsheelP.RaghavendraA

this profile minimizes unintended chronotropic or neurologic effects while sparing skeletal muscle and retinal phototransduction

cost and convenience favor oral once stable

In some embodiments, the otic formulation or composition comprises between about 0.001% to about 99.99% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof