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276 Pathological prion instigates neuronal death, which in turn causes secondary astrocytic reactivity predominantly in the white matter, but the roles of reactive astroglia in prion diseases are poorly understood and hampered by the emerging complexity of astrocyte responses to prion induced pathologies

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The high sensitivity but lower specificity of the HepG2 cell model with hamster S9-mix therefore makes the model useful when a conservative approach to avoid false-negative results is the goal of the test strategy