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These effects of semaglutide on your metabolism can help you burn more calories and fat, and improve your metabolic health

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While semaglutide only targets and binds to GLP-1 receptors, tirzepatide is a dual agonist that acts on both GLP-1 and GIP receptors

Broom I, Wilding J, Stott P, Myers N, UK Multimorbidity Study Group

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The moderate approach suggests that patients already tolerating a GLP-1 medication can often start tirzepatide at 5 mg safely