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This is why Lyme fatigue is so severe, and it's not muscular tiredness, it's all about the cellular energy failure

doi: 10.2903/j.efsa.2020.6040 204

Some experimental results show that the organ index of the testicular tissue is lower in rats in a simulated plateau environment with low-pressure and low-oxygen environment compared with the control group, indicating that the low pressure and high altitude may cause damage to the rats testicular tissue and result in atrophy or degeneration or a decreased organ index [4, 31,32,33,34,35]