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Co-targeting the HER and IGF/insulin receptor axis in breast cancer, with triple targeting with endocrine therapy for hormone-sensitive disease

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Genetics also play a role in the development of melanoma, potentially explaining cases of melanoma that occur in parts of the body not typically exposed to the sun

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Treatment must be initiated within specialist weight management services (Tier 3) as part of a comprehensive programme that includes dietary modification, increased physical activity, and behavioural support