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The study design was two randomized, placebo-controlled, double-blind, ascending dose trials with durations of 28 and 49 days

, 2010), to include genes involved in GSH synthesis ( GSS , GCLC , and GCLM ), GSH redox status ( GSR , GPX1 , GPX2 , GPX3 , GPX4 , GPX5 , GPX6 , and GPX7 ), GSH S -transferases ( GSTA1 , GSTA2 , GSTA3 , GSTA4 , GSTA5 , GSTM1 , GSTM2 , GSTM3 , GSTM4 , GSTM5 , GSTO1 , GSTO2 , GSTP1 , GSTT1 , GSTT2 , and GSTZ1 ), and GSH conjugate transporters ( ABCC1 , ABCC2 , ABCC3 , and ABCC4 )

Upper Arm: Injections in the upper arm should be rotated within the fatty area of the outer arm, varying the location slightly up or down each time

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Bowman, G