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The difference is mainly in how the brackets are planned and placed

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Prior medications during hospitalization, patient stress and variable but unavoid-able delays between death and tissue procurement may also be confoundable variables

Entomol Experimentalis Applicata (2012) 142(1):116

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Pro-Opiomelanocortin (POMC) Deficiency Obesity & Leptin Receptor (LEPR) Deficiency Obesity These conditions result from mutations affecting appetite regulation, causing excessive hunger and severe obesity from an early age