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Always follow these specific guidelines rather than general advice

[6] The American Association of Clinical Endocrinology (AACE) guidelines for obesity management similarly recommend comprehensive metabolic evaluation prior to weight loss pharmacotherapy, including thyroid assessment when clinically indicated

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Tirzepatide: the GIP potentiation effect Tirzepatide is a 39-amino-acid peptide biased toward GIP (5 higher affinity for GIPR than GLP-1R)