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By persistently reducing nutrient inflow while maintaining or redistributing oxidative demand, GLP-1RA therapy establishes a state of chronic energy flux constriction

The synergy works at two levels

According to the German Diabetes Centre (DDZ), about 8.5 million people in Germany are affected by diabetes

Specifically, the use of ibogaine, due to its pro-arrhythmic properties and prolonged active half-life, necessitates administration protocols with continuous electrocardiographic monitoring and immediate clinical support [61]