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In addition, vitamin D may exert indirect antifibrotic effects by upregulating bone morphogenetic protein-7 (BMP-7) or alleviating oxidative stress and inflammation (36)

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Other common gastrointestinal side effects include: Diarrhoea loose or frequent bowel movements affecting 20-30% of patients Constipation paradoxically, some patients experience reduced bowel frequency Abdominal pain or discomfort cramping or generalised abdominal discomfort Dyspepsia indigestion, bloating, or upper abdominal fullness Decreased appetite whilst this is part of the therapeutic effect, it can feel uncomfortable Beyond gastrointestinal symptoms, patients may experience other effects that contribute to feeling unwell

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