Mielgo-Ayuso, J., Marques-Jimnez, D., Refoyo, I., Del Coso, J., Len-Guereo, P., & Calleja-Gonzlez, J
Effects of resistance exercise training on oxidative stress and inflammation Chronically elevated oxidative stress and diminished antioxidant defenses causes neuronal damage and mitochondrial dysfunction, which play key roles in neurodegenerative pathologies (Guo et al., 2013)
Additionally, GHRP-2 has been found to be orally bio-active, and is used as a test peptide for assessing growth hormone deficiency and secondary adrenal failure
Medical Considerations Low IGF-1 with symptoms of GH deficiency may warrant: GH stimulation testing Consideration of GH or peptide therapy under endocrinology or functional medicine guidance High IGF-1 may require: Acromegaly screening (IGF-1 + oral glucose tolerance GH suppression test) Adjustment of therapy dosages Cancer risk assessment and monitoring IGF-1, Longevity, and Health Span The relationship between IGF-1 and lifespan is U-shaped both extremes are associated with higher risk
2025 Aug 23;17(1):352
10.1016/j.phymed.2024.155649 43 ZhaoB.YuJ.LuoY.XieM.QuC.ShiQ.et al (2023)
