In the STEP 1 trial, nausea, diarrhoea, vomiting or constipation affected around 74% of people on semaglutide, compared with about 48% on placebo, and a small number stopped treatment because of side effects
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TMAO and atherosclerosis Atherosclerosis, which is the major risk factor of CVDs, is characterized by foam cell formation, inflammatory cell recruitment, and endothelial dysfunction (61)
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