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PT-141 was deemed safe enough to be granted approval by the US FDA in 2019 and has not been found to cause serious adverse events or side effects at a statistically significant rate [10]

544 Additionally, metformin increases glucose uptake in muscle by activating insulin receptor tyrosine kinase, partly by promoting GLUT4 translocation to the cell membrane

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As of now, there are no published clinical trials or studies in the UK validating its safety, efficacy, or long-term results

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