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For a 250-pound person, this would translate to about 52.5 pounds

Even so, the FDA noted that it could not rule out a small risk because isolated cases of suicidal thoughts or actions have been reported in people using GLP-1 drugs

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Immunohistochemistry Tissues were fixed in 4% paraformaldehyde overnight at 4 C, followed by cryoprotection in 30% sucrose overnight, and finally snap-freezing

In the brain, GLP-1Rs are found in several hindbrain and forebrain sites, including areas that are implicated in the control of food intake and regulation of energy balance, such as the area postrema (AP), the nucleus tractus solitarius (NTS), hypothalamus, amygdala, and in the mesolimbic reward system