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Specifically, IGFBP3 was reported to inhibit tumorigenesis and cell growth, and IGFBP5 was suggested to function as a tumor suppressor [42,43,44,45]

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In addition, although the domestically developed PD-1 inhibitors toripalimab and tislelizumab were associated with relatively smaller overall numbers of adverse event reports, both agents demonstrated disproportionately high signal strength for immune-mediated lung disease and interstitial lung disease