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Complementary work has documented activation of the VEGFR2 (Vascular Endothelial Growth Factor Receptor 2) pathway, involved in angiogenesis, along with upregulation of early growth response genes (Egr-1) and the FAK-paxillin transcription factor in studied endothelial cells

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For patients with type 2 diabetes, reduced potency may manifest as elevated hemoglobin A1c levels , increased fasting glucose readings, or loss of previously achieved glycemic control

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