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Third, altered microbial metabolism may shift the balance away from SCFA-rich, tolerance-supporting conditions toward lipopolysaccharide-rich, low-grade inflammatory states

Dopamine o -quinone is not stable in the cytosol at physiological pH and its amino chain cyclizes (reaction 5), generating aminochrome (Figure 3)

2010, 126: e17-22

Mild effects can include a temporary warm sensation, flushing, or slight bruising at the injection site

Why an imbalance between Phase I and II matters: Phase I detoxification processes often make a lipophilic (lipid-soluble) substance more hydrophilic for increased solubility